HDAC11-IN-2

CAT: 0931-MF-0113947-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0113947-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2919766-97-3
Target
AMPK|||HDAC
Related Pathways
Chromatin/Epigenetic|||DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling
Bioactivity
HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11) . It demonstrates IC50 values of 51.1 x10^-3 ?M for HDAC11 and 5 ?M for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPK?1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.
Smiles
O=C(NNCCCCCOCCCCC)C1=CC=C(C=C1)CNC(=O)C=2C=CC=CC2
Molecular Formula
C25H35N3O3
Molecular Weight
425.564
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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