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VEN-02XX

CAT: 0931-T207260-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207260-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.
Smiles
CC(C)(O)CNC1=NN=C(C2=CC=C(Cl)C=C2C(F)(F)F)C3=C1C=NC=C3
Molecular Formula
C18H16ClF3N4O
Molecular Weight
396.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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