Products for Research Use Only

VEN-02XX

CAT: 0013-GTR19257916-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257916-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEN-02XX is an orally active NLRP3 inhibitor capable of penetrating the brain. It effectively suppresses the release of IL-1β and IL-18, with IC50 values of 0.3 and 0.28 μM, respectively. In the 5XFAD/Rubicon KO mouse model, VEN-02XX aids in restoring memory and cognition, inhibits microgliosis, and alleviates neuroinflammation and tau protein pathology. This compound is valuable for Alzheimer's disease (AD) research.
Field of Research
Immunology & Inflammation
Smiles
CC (C) (O) CNC1=NN=C (C2=CC=C (Cl) C=C2C (F) (F) F) C3=C1C=NC=C3
Molecular Formula
C18H16ClF3N4O
Molecular Weight
396.79
Storage Conditions
-20°C
Notes
For research use only.