LC-SF-14

CAT: 0931-T207213-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207213-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

P38 MAPK, FGFR, Phosphatase, ERK

Related Pathways

MAPK, Tyrosine Kinase/Adaptors, Angiogenesis, Metabolism

Bioactivity

LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM) . Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.

Molecular Formula

C44H50Cl3N13O5S

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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