LC-SF-14

• Target:

  P38 MAPK|||FGFR|||Phosphatase|||ERK

• Related Pathways:

  MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Metabolism

• Bioactivity:

  LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2?-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM) . Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.

• Molecular Formula:

  C44H50Cl3N13O5S

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C