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LC-SF-14

CAT: 931-T207213-01Size: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
P38 MAPK|||FGFR|||Phosphatase|||ERK
Related Pathways
MAPK|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Metabolism
Bioactivity
LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2?-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM) . Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.
Molecular Formula
C44H50Cl3N13O5S
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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