FLY26

CAT: 0931-T207202-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T207202-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Reactive Oxygen Species, Trk receptor, iGluR

Related Pathways

Neuroscience, Metabolism, Tyrosine Kinase/Adaptors, NF-κB, Membrane transporter/Ion channel, Immunology/Inflammation

Bioactivity

FLY26 is a selective partial antagonist of GluN2B, with an IC50 value of 0.64 μM. FLY26 inhibits the GluN2B subunit of NMDA receptors, reducing calcium ion influx and reactive oxygen species (ROS) production. It also activates the BDNF/TrkB/CREB neuroprotective signaling pathway, mitigating excitotoxicity and mitochondrial dysfunction. FLY26 holds potential for treating neurological deficits caused by cerebral ischemia-reperfusion injury.

Molecular Formula

C22H23N5O3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
HY-172876	FLY26

FLY26

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