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DNJ-20

CAT: 0931-T207025-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207025-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3081926-49-7
Target
SARS-CoV, glycosidase
Related Pathways
Microbiology/Virology, Metabolism
Bioactivity
DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL. It exhibits broad-spectrum activity against SARS-CoV-2. By interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), DNJ-20 hinders the proper processing of viral glycoproteins, thus blocking the formation and infection of viral particles. It is effective against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43, with IC50 values reaching up to 1.49 μM. DNJ-20 can be utilized for pan-coronavirus research.
Smiles
O(CCCCCCCCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1)C2=C3C(OC(=CC3=O)C4=CC(O)=C(O)C=C4)=CC(O)=C2
Molecular Formula
C31H41NO10
Molecular Weight
587.658
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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