DNJ-20

• Target :

  SARS-CoV|||glycosidase

• Related Pathways :

  Microbiology/Virology|||Metabolism

• Bioactivity :

  DNJ-20 is an ?-glucosidase inhibitor with an IC50 of 55.3 ?g/mL. It exhibits broad-spectrum activity against SARS-CoV-2. By interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), DNJ-20 hinders the proper processing of viral glycoproteins, thus blocking the formation and infection of viral particles. It is effective against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43, with IC50 values reaching up to 1.49 ?M. DNJ-20 can be utilized for pan-coronavirus research.

• Smiles :

  O(CCCCCCCCCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1)C2=C3C(OC(=CC3=O)C4=CC(O)=C(O)C=C4)=CC(O)=C2

• Molecular Formula :

  C31H41NO10

• Molecular Weight :

  587.658

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3081926-49-7