TYD-68

• Target:

  JAK|||STAT|||PROTACs

• Related Pathways:

  Chromatin/Epigenetic|||Angiogenesis|||Stem Cells|||PROTAC|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling

• Bioactivity:

  TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-?-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C