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HCES2A-IN-2

CAT: 0931-T206726-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206726-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Lipid
Related Pathways
Metabolism
Bioactivity
HCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible, covalent inhibitor of hCES2A with an IC50 of 0.04 nM. It targets and covalently binds to the catalytic serine residue (Ser-228) of hCES2A. hCES2A-IN-2 can significantly mitigate irinotecan-induced gastrointestinal toxicity (ITGT) without diminishing the antitumor efficacy of irinotecan in tumor-bearing mice.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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