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LA-CB1

CAT: 0013-GTR19258547-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258547-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis) . It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 μM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.
CAS Number
3032908-44-1
Field of Research
Cell Biology, Neuroscience
Smiles
N#CC1=CC=CN=C1COC2=CC=C (C=C2Cl) NC=3N=CC=C (N3) C=4C=C (F) C=5N=C (N (C5C4) C (C) C) C
Molecular Formula
C28H23ClFN7O
Molecular Weight
527.98
Storage Conditions
-20°C
Notes
For research use only.

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