PUC-10

• Target :

  5-HT Receptor|||mTOR|||Autophagy

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Neuroscience|||GPCR/G Protein|||Autophagy

• Bioactivity :

  PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. Computer simulations suggest that PUC-10 is orally active and capable of crossing the blood-brain barrier. It induces autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 is applicable in the study of neurological disorders.

• Smiles :

  S(=O)(=O)(N1C=2C(C([C@@H](CN3CCN(CC3)C4=C(OC)C=CC=C4)O)=C1)=CC=CC2)C=5C6=C(C=CC5)C=CC=C6

• Molecular Formula :

  C31H31N3O4S

• Molecular Weight :

  541.661

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2095549-31-6