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PUC-10

CAT: 0931-T206402-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T206402-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2095549-31-6
Target
5-HT Receptor|||mTOR|||Autophagy
Related Pathways
PI3K/Akt/mTOR signaling|||Neuroscience|||GPCR/G Protein|||Autophagy
Bioactivity
PUC-10 is a 5-HT6 receptor antagonist with a Ki of 14.6 nM and an IC50 of 32 nM. Computer simulations suggest that PUC-10 is orally active and capable of crossing the blood-brain barrier. It induces autophagy in SH-SY5Y cells by inhibiting the mTOR pathway. PUC-10 is applicable in the study of neurological disorders.
Smiles
S(=O)(=O)(N1C=2C(C([C@@H](CN3CCN(CC3)C4=C(OC)C=CC=C4)O)=C1)=CC=CC2)C=5C6=C(C=CC5)C=CC=C6
Molecular Formula
C31H31N3O4S
Molecular Weight
541.661
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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