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5-HT2B antagonist-2

CAT: 0931-T206366-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206366-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
5-HT Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Bioactivity
5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. It effectively downregulates the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, significantly reducing cellulose deposition. In a CCl4-induced liver fibrosis mouse model, it decreases the fibrotic area and inhibits the progression of fibrosis. This compound is useful for research into immune-inflammatory related diseases, particularly pulmonary fibrosis.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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