EGFR-IN-154

CAT: 0931-T206154-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206154-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

EGFR, JNK, p38 MAPK, Akt, PERK

Related Pathways

Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, JAK/STAT signaling, Apoptosis, MAPK, Cytoskeletal Signaling, Angiogenesis

Bioactivity

EGFR-IN-154 (compound 4c) is an EGFR inhibitor with EC0 values of 0.16 μM for EGFRDel19, 21.73 μM for EGFR WT, and 41.56 μM for EGFRL858R. This compound exhibits anticancer activity across various cancer cell lines. EGFR-IN-154 induces mitochondrial apoptosis, reduces pERK1/2 and pAkt levels, and increases pJNK and pp38 levels.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
GTR19258734-01	EGFR-IN-154
B7585-10	PE 154
BW170171-01	WWL 154
MBS3607362-01	HMN-154
MBS3616248-01	ML 154
7395/5	MS 154
HY-164893-01	ABBV-154
HY-153015-01	AAZ-A 154
LBA40215-01	PBB 154

EGFR-IN-154

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