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DNMT1-IN-5

CAT: 0931-T205711-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205711-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2982511-19-1
Target
Apoptosis|||DNA Methyltransferase
Related Pathways
Apoptosis|||Chromatin/Epigenetic
Bioactivity
DNMT1-IN-5 (Compound 55) is an inhibitor of DNMT, specifically targeting DNMT1 and DNMT3A, with IC50 values of 2.42 ?M and 14.4 ?M, respectively. It demonstrates antiproliferative effects across various cancer cell lines (TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116) with IC50 values ranging from 0.19 to 2.37 ?M. The compound induces G2/M phase cell cycle arrest and apoptosis in TMD-8 and DOHH2 cells. Additionally, DNMT1-IN-5 exhibits antitumor efficacy in a TMD-8 xenograft mouse model.
Smiles
FC1=NC=CC(=C1)C=2N=C(NC3CCN(C)CC3)C=4C=CN(C4N2)CCCN5CCCC5
Molecular Formula
C24H32FN7
Molecular Weight
437.556
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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