LC3B recruiter 2

CAT: 0931-T205700-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205700-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

380636-64-6

Target

ATTECs, ATG, Autophagy

Related Pathways

PROTAC, Autophagy

Bioactivity

LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.

Smiles

O=C1NC2=CC(Cl)=CC=C2C(=O)N1CC

Molecular Formula

C10H9ClN2O2

Molecular Weight

224.644

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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