PPIA-IN-1

CAT: 0931-T205696-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205696-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Reactive Oxygen Species, p38 MAPK, Apoptosis, ROS

Related Pathways

MAPK, Apoptosis, Immunology/Inflammation, NF-κB, Metabolism

Bioactivity

PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 μM. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 μM in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.

Molecular Formula

C23H21Cl2FN4O7

Molecular Weight

555.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-172209-01	PPIA-IN-1
CSB-CL351810HU3	PPIA
PVT37699	pExpress-1-Ppia Plasmid
P28585	PExpress-1-Ppia (rat)
10R-3111	PPIA antibody
393266-01	PPIA discontinued
DF6175-BP	PPIA Peptide

PPIA-IN-1

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