PPIA-IN-1

• Target:

  Reactive Oxygen Species|||p38 MAPK|||Apoptosis|||ROS

• Related Pathways:

  MAPK|||Apoptosis|||Immunology/Inflammation|||NF-?B|||Metabolism

• Bioactivity:

  PPIA-IN-1 (Compound 20b) is an inhibitor of peptidyl-prolyl isomerase A (PPIA) with a KD of 0.52 ?M. It demonstrates antiproliferative activity across various cancer cell lines, including an IC50 of 0.69 ?M in HCT116 cells, induces cell cycle arrest at the G0/G1 phase, and exhibits antimetastatic effects in HCT116 cells. PPIA-IN-1 elevates ROS levels, causing DNA damage, ER stress, and mitochondrial dysfunction, and induces apoptosis in HCT116 cells via the MAPK pathway. Additionally, PPIA-IN-1 shows antitumor activity in a CT26 xenograft mouse model.

• Molecular Formula:

  C23H21Cl2FN4O7

• Molecular Weight:

  555.34

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C