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CIB-L43

CAT: 0931-T205607-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T205607-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1082942-70-8
Target
TGF-beta/Smad, PTEN, Akt, DNA/RNA Synthesis
Related Pathways
Stem Cells, DNA Damage/DNA Repair, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint
Purity
0.9964
Bioactivity
CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.
Smiles
O=C(O)C=1SC(=NC1C)C=2C=CC(=CC2)N3CCOCC3
Molecular Formula
C15H16N2O3S
Molecular Weight
304.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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