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M3686

CAT: 0931-T205477-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205477-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2738550-24-6
Target
YAP
Related Pathways
Stem Cells
Bioactivity
M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.
Smiles
CN1N=C2N(C=3C(C2=N1)=CC(C(=O)N4CC[C@H](O)C4)=CC3)C5=CC=C(C(F)(F)F)C=C5
Molecular Formula
C21H18F3N5O2
Molecular Weight
429.395
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-170764M3686

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