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M3686

CAT: 0013-GTR19249300-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249300-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M3686 (Compound 29) is a potent, selective TEAD1 inhibitor (IC50 = 51 nM) with weaker activity against TEAD3. It potently inhibits YAP-dependent transcription in NCI-H226 cells (IC50 = 0.06 μM) and demonstrates significant in vivo antitumor efficacy in NCI-H226 xenograft models, supporting research in Hippo pathway signaling and cancer.
CAS Number
2738550-24-6
Field of Research
Stem Cell & Developmental Biology
Smiles
CN1N=C2N (C=3C (C2=N1) =CC (C (=O) N4CC[C@H] (O) C4) =CC3) C5=CC=C (C (F) (F) F) C=C5
Molecular Formula
C21H18F3N5O2
Molecular Weight
429.395
Storage Conditions
-20°C
Notes
For research use only.

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