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VISTA-IN-4

CAT: 0931-T205442-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205442-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
VISTA-IN-4 (Compound B3) is an orally active inhibitor of the immune checkpoint protein VISTA, with a KD of 0.452 μM. It degrades VISTA in HepG2 cells with a degradation rate of 77% at a concentration of 5 μM. VISTA-IN-4 counteracts VISTA-mediated immune suppression, restoring T cell activity and promoting the release of cytokine IL-2. Additionally, it exhibits antitumor activity in CT26 xenograft mouse models and demonstrates favorable pharmacokinetic properties, with good oral serum exposure in SD rats, reflected by an AUC (0-t) of 412.9 mg·h/mL.
Molecular Formula
C24H25FN4
Molecular Weight
388.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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