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AR antagonist 10

CAT: 0931-T205420-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205420-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3068489-78-8
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Bioactivity
AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.
Smiles
O=C(NC1=NC(=NS1)CN2CCOCC2)C=3C=COC=4C=CC(Cl)=CC4C3
Molecular Formula
C18H17ClN4O3S
Molecular Weight
404.871
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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