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EMT inhibitor-3

CAT: 0931-T205130-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205130-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2930726-89-7
Target
Bcl-2 Family, Caspase, Apoptosis, Cytochromes P450
Related Pathways
Metabolism, Proteases/Proteasome, Apoptosis
Bioactivity
EMT inhibitor-3 (compound 11i) is an epithelial-mesenchymal transition (EMT) inhibitor that effectively suppresses the proliferation, migration, and invasion of SK-N-SH neuroblastoma cells, with an IC50 value of 2.5 μM. It induces mitochondrial-mediated intrinsic apoptosis in tumor cells by enhancing the Bax/Bcl-2 protein expression ratio, promoting the release of cytochrome C from mitochondria, and activating caspase 9 and caspase 3. EMT inhibitor-3 is applicable for cancer research.
Smiles
N#C[Se]CCCOC=1C=CC=2C=C(C(=O)OC2C1)C(=O)N3N=C(C=4C=CC(F)=CC4)CC3C5=CC=C(F)C=C5
Molecular Formula
C29H21F2N3O4Se
Molecular Weight
592.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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