TS-IN-5

• Target:

  DNA/RNA Synthesis|||Bcl-2 Family|||Apoptosis|||PI3K|||STAT

• Related Pathways:

  Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Stem Cells|||JAK/STAT signaling|||Apoptosis|||DNA Damage/DNA Repair

• Bioactivity:

  TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS) . It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.

• Smiles:

  CN1CCN(CC1)C2=NC=C(C(=O)N2)C3=NC4=CC=CC=C4S3

• Molecular Formula:

  C16H17N5OS

• Molecular Weight:

  327.404

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C