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HGC652

CAT: 0931-T204670-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204670-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3055558-98-7
Target
E1/E2/E3 Enzyme, Molecular Glues
Related Pathways
Ubiquitination, PROTAC
Bioactivity
HGC652 is a molecular glue that targets the E3 ubiquitin ligase TRIM21, facilitating the formation of a ternary complex between TRIM21 and NUP98, which induces the degradation of NUP155 and nuclear pore complex proteins, ultimately leading to cell death. HGC652 inhibits the proliferation of various cancer cells, with its antiproliferative activity depending on the expression level of TRIM21.
Smiles
O=C(C=1C=CC(=CC1S(=O)(=O)C)C2=CC=C(F)C=C2SC)N(C)CC3CCCCC3
Molecular Formula
C23H28FNO3S2
Molecular Weight
449.602
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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