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P38-α MAPK-IN-8

CAT: 0931-T204486-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204486-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, p38 MAPK, Reactive Oxygen Species, ROS
Related Pathways
Metabolism, Apoptosis, MAPK, NF-κB, Immunology/Inflammation
Bioactivity
P38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. It exhibits cytotoxicity toward various tumor cells, inducing cell cycle arrest and apoptosis, as well as increasing reactive oxygen species (ROS) production and causing mitochondrial membrane potential depolarization. Its antitumor activity may be related to the p38α MAPK pathway, making it a potential candidate for cancer research.
Smiles
C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)OC(=O)CCC[P+](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)C)C)C)OC1.[Br-]
Molecular Formula
C49H62BrO4P
Molecular Weight
825.892
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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