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Tilatamig samrotecan

CAT: 0931-T204443-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T204443-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
DNA/RNA Synthesis, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
Tilatamig samrotecan (AZD9592) is an antibody-drug conjugate (ADC) designed to deliver a topoisomerase I inhibitor (TOP1i) . It targets epidermal growth factor receptor (EGFR) and c-MET and demonstrates antitumor activity. The compound induces DNA double-strand breaks, elevates pRAD50 and γH2AX expression, and inhibits the growth of non-small cell lung cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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