YB-3–17

• Target:

  MTOR|||PROTACs

• Related Pathways:

  PROTAC|||PI3K/Akt/mTOR signaling

• Bioactivity:

  YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

• Smiles:

  O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NCC4CCC(C(=O)N5CCC(N6N=C(C=7C=CC=8OC(=NC8C7)N)C=9C(=NC=NC96)N)CC5)CC4)CC1

• Molecular Formula:

  C38H39N11O6

• Molecular Weight:

  745.786

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2940242-88-4