CLPP-2068

• Target :

  ROS|||Apoptosis|||Protease

• Related Pathways :

  Proteases/Proteasome|||Apoptosis|||Immunology/Inflammation

• Bioactivity :

  CLPP-2068 has oral activity and is an activator of human casein hydrolase P (HsClpP) (EC50=50.4 nM) . CLPP-2068 exhibits anti proliferative effects (IC50=5.2 nM) in OCI-LY10 cells, and can also reduce mitochondrial membrane potential, increase mitochondrial ROS levels, and induce mitochondrial dysfunction. CLPP-2068 blocks the cell cycle in G1 phase and induces apoptosis in OCI-LY10 cells. CLPP-2068 exhibits anti-tumor activity in a mouse xenograft model.

• Smiles :

  O=C1NC(NCC2=CC=C(Br)C=C2)=NC3=C1CN([C@H](C)C3)CC4=CC(C#N)=CC=C4

• Molecular Formula :

  C23H22BrN5O

• Molecular Weight :

  464.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C