JCS-1

CAT: 0931-T203316-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T203316-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

PROTACs, Phosphatase

Related Pathways

Metabolism, PROTAC

Bioactivity

JCS-1 is a potent DcpSPROTAC degrader. It non-covalently binds to DcpS via an RG3039-based warhead and recruits the E3 ligase VHL. JCS-1 facilitates the ubiquitination and degradation of DcpS at nanomolar concentrations, with a DC50 of 87 nM in MOLM-14 cells. This compound can be utilized in research on acute myeloid leukemia and other DcpS-dependent genetic disorders.

Molecular Formula

C62H79N9O12S

Molecular Weight

1174.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19241325-01	JCS-1
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N2864-5.1	1,1,1,1-Kestohexaose
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OR312388	1-Phenylbicyclo[1.1.1]pentane
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JCS-1

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