PPL agonist-1

• Target:

  Microtubule Associated|||Tyrosinase

• Related Pathways:

  Proteases/Proteasome|||Cytoskeletal Signaling

• Bioactivity:

  PPL agonist-1 (Compound I-3) is a highly selective agonist of Periplakin (PPL) that raises cAMP levels by modulating PPL, enhancing MITF expression, and consequently promoting melanin synthesis. Additionally, it stimulates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib, PPL agonist-1 demonstrates superior effectiveness and holds potential for vitiligo research.

• Smiles:

  CC=1C=C(C2=CC=C([C@@H](NC=3N=C(NS(=O)(=O)C4=CC(N(=O)=O)=CC=C4)C=CN3)C)C=C2)C=CC1F

• Molecular Formula:

  C25H22FN5O4S

• Molecular Weight:

  507.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3040997-52-9