Products for Research Use Only
RegisterLogin

AGU654

CAT: 0931-T203185-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T203185-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
3038861-74-1
Target
PGE Synthase
Related Pathways
Immunology/Inflammation
Bioactivity
AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC50 value of 2.9 nM against mPGES-1. By inhibiting mPGES-1, AGU654 interrupts the pathway where COX-1/2 converts arachidonic acid to prostaglandin E2 (PGE2), effectively reducing inflammatory responses, pain, and fever symptoms. In models using activated human monocyte-derived macrophages and whole blood, AGU654 selectively inhibits PGE2 production induced by bacterial endotoxins, while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, demonstrating excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a new approach for researching inflammatory diseases and pain.
Smiles
O=C(NC=1C=CC(=CC1)C2=NC3=CC=C(C=C3N2)C(F)(F)F)C4=CC(=CC=C4Cl)CNC(=O)C5(CC5)C(F)(F)F
Molecular Formula
C27H19ClF6N4O2
Molecular Weight
580.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-169430AGU654

Popular Products