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O-Desmethylcarvedilol

CAT: 0931-T203083-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203083-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
72956-44-6
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism
Bioactivity
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 μM) . Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 μg/kg) .
Smiles
OC=1C=CC=CC1OCCNCC(O)COC2=CC=CC=3NC=4C=CC=CC4C23
Molecular Formula
C23H24N2O4
Molecular Weight
392.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
OR1075408O-Desmethylcarvedilol
MBS6025024-01(R)-(+)-O-Desmethylcarvedilol
D3220-86QS- (-) -O-Desmethylcarvedilol
D3220-86P(R) - (+) -O-Desmethylcarvedilol
MBS6038647-01(S)-(-)-O-Desmethylcarvedilol
B1077-96VS- (-) -O-Benzyl-O-desmethylcarvedilol
MBS6108169-01(S)-(-)-O-Benzyl-O-desmethylcarvedilol
sc-220038(S) - (-) -O-Benzyl-O-desmethylcarvedilol
MBS6089296-012'-O-Benzyloxy-2-O-desmethylcarvedilol
B1078-02W2’-O-Benzyloxy-2-O-desmethylcarvedilol

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