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MN-25

CAT: 0931-T203060-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203060-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
501926-82-5
Target
Cannabinoid Receptor, TNF
Related Pathways
Apoptosis, GPCR/G Protein
Bioactivity
MN-25 (compound 4a) is an orally active indole pyridinone that functions as a novel cannabinoid ligand. It exhibits binding affinities (Ki) of 245 nM for CB1 and 11 nM for CB2 receptors. As a CB2 agonist, MN-25 inhibits TNF-R release from human peripheral blood mononuclear cells in vitro, with an IC50 of 33 μM. However, in an acute inflammation model in mice, MN-25 did not demonstrate efficacy at oral doses up to 50 mg/kg.
Smiles
C(CN1CCOCC1)N2C=3C(C(C(N[C@H]4[C@]5(C)C[C@](C4(C)C)(CC5)[H])=O)=C2)=CC=CC3OC
Molecular Formula
C26H37N3O3
Molecular Weight
439.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

7-Methoxy-1-(2-morpholinoethyl)-N-((1S,4R)-1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-1H-indole-3-carboxamide
CAS Number501926-82-5
PubChem CID71308243
IUPAC Name7-methoxy-1-(2-morpholin-4-ylethyl)-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]indole-3-carboxamide
Molecular FormulaC26H37N3O3
Molecular Weight439.6
XLogP3.8
Topological Polar Surface Area55.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity694
SMILES
C[C@]12CC[C@H](C1)C([C@H]2NC(=O)C3=CN(C4=C3C=CC=C4OC)CCN5CCOCC5)(C)C
InChI
InChI=1S/C26H37N3O3/c1-25(2)18-8-9-26(3,16-18)24(25)27-23(30)20-17-29(11-10-28-12-14-32-15-13-28)22-19(20)6-5-7-21(22)31-4/h5-7,17-18,24H,8-16H2,1-4H3,(H,27,30)/t18-,24-,26+/m1/s1
InChIKey
VQGDMQICNRCQEH-UFKXBGGNSA-N
Chemical Structure
2D Structure
2D structure of 7-Methoxy-1-(2-morpholinoethyl)-N-((1S,4R)-1,3,3-trimethylbicyclo(2.2.1)heptan-2-yl)-1H-indole-3-carboxamide
CAS: 501926-82-5
CID: 71308243
Formula: C26H37N3O3
MW: 439.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.6
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass439.28349205
Monoisotopic Mass439.28349205
Topological Polar Surface Area55.7 Ų
Heavy Atom Count32
Formal Charge0
Complexity694
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
M14692MN-25
S8060-25ASuperoxide Dismutase, Mn (SOD Mn) discontinued, see S8060-25
13003P-25μgMn Superoxide Dismutase (13003P) - 25 μg
S8060-10B-01Superoxide Dismutase, Mn (SOD Mn)
YP-W17156-01Human MN (MN) ELISA Kit
YP-W36077-01Rat MN (MN) ELISA Kit
S8060-25-PESuperoxide Dismutase, Mn (SOD Mn) (PE)
S8060-25-APCSuperoxide Dismutase, Mn (SOD Mn) (APC)
S8060-25-HRPSuperoxide Dismutase, Mn (SOD Mn) (HRP)
S8060-25-FITCSuperoxide Dismutase, Mn (SOD Mn) (FITC)

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