MN-25

• Target:

  Cannabinoid Receptor|||TNF

• Related Pathways:

  Apoptosis|||GPCR/G Protein

• Bioactivity:

  MN-25 (compound 4a) is an orally active indole pyridinone that functions as a novel cannabinoid ligand. It exhibits binding affinities (Ki) of 245 nM for CB1 and 11 nM for CB2 receptors. As a CB2 agonist, MN-25 inhibits TNF-R release from human peripheral blood mononuclear cells in vitro, with an IC50 of 33 ?M. However, in an acute inflammation model in mice, MN-25 did not demonstrate efficacy at oral doses up to 50 mg/kg.

• Smiles:

  C(CN1CCOCC1)N2C=3C(C(C(N[C@H]4[C@]5(C)C[C@](C4(C)C)(CC5)[H])=O)=C2)=CC=CC3OC

• Molecular Formula:

  C26H37N3O3

• Molecular Weight:

  439.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  501926-82-5