Mn (III) TMPyP

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  Mn (III) TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-reactions in addition to the dismutation of the superoxide radical (O2-) . Mn (III) TMPyP is an SOD mimetic with increased stability to pH and hydrogen peroxide. The rate constant for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M-1s-1 and ~2 x 106 M-1s-1, respectively. Mn (III) TMPyP protected and enhanced the growth of SOD E. coli with a doubling time of 60 minutes (as compared to 240 minutes of the control) at 25 µM.

• Smiles:

  [Cl-].[Cl-].[Cl-].[Cl-].C[n+]1ccc(cc1)C1=C2\C=CC(=N\2)C(c2cc[n+](C)cc2)=c2ccc3=C(C4=N\C(\C=C4)=C(/c4ccc\1n4[Mn](Cl)n23)c1cc[n+](C)cc1)c1cc[n+](C)cc1

• Molecular Formula:

  C44H36Cl5MnN8

• Molecular Weight:

  909.013

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C