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VZMC013

CAT: 0931-T202992-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T202992-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
VZMC013 is a potent chemical probe targeting the MOR-CCR5 heterodimer, effectively inhibiting HIV-1 entry exacerbated by opioid compounds. It exhibits nanomolar binding affinity to both MOR and CCR5, inhibits CCL5-activated calcium mobilization, and significantly enhances anti-HIV-1BaL activity compared to previously reported bivalent ligands. In TZM-bl cells co-expressing CCR5 and MOR, VZMC013 demonstrates greater inhibition of viral infection than in cells expressing only CCR5. Additionally, VZMC013 blocks HIV-1 entry into peripheral blood mononuclear cells (PBMC) in a concentration-dependent manner and more effectively inhibits opioid-accelerated HIV-1 entry in phytohemagglutinin-activated PBMC than in opioid-free environments.
Smiles
O=C(COCC(NCCCCCCCNC(COCC(NCCC1=NN=C(C(C)C)N1[C@H]2C[C@H]3N(CC[C@H](NC(C4CCC(F)(F)CC4)=O)C5=CC=CC=C5)[C@H](CC3)C2)=O)=O)=O)N[C@H](CC6)C7[C@]([C@]6(O)[C@H]8C9)(CCN8CC%10CC%10)C%11=C9C=CC(O)=C%11O7
Molecular Formula
C65H92F2N10O10
Molecular Weight
1211.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19242401-01VZMC013

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