DOTA-NT-20.3

CAT: 0931-T201961-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201961-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1262311-97-6

Bioactivity

68Ga-DOTA-NT-20.3 is an analogue of neurotensin (NTS) and acts as a ligand for 68Ga ions. In PET imaging, it demonstrates rapid tumor uptake and high contrast between tumor and background, along with fast clearance from the blood and moderate accumulation in the kidneys. Its pharmacokinetic and biodistribution properties are advantageous, producing high-quality PET images in mice with subcutaneous or orthotopic human pancreatic cancer xenografts. 68Ga-DOTA-NT-20.3 specifically binds to NTSR1 on pancreatic cancer cells and outperforms 18F-FDG in PET detection of adenocarcinoma.

Smiles

C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@@](C)(C)C)=O)(=O)[C@H]2N(C([C@@H](NC([C@@H](N(C(=O)[C@H]3N(C([C@H](CCCCNC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)NC(C)=O)=O)CCC3)C)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC2

Molecular Formula

C68H113N19O18

Molecular Weight

1484.74

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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