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DSPE-PEG (2000) -Mannose

CAT: 0931-T201883-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T201883-02Size:50 mg
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CAS Number
1829524-73-3
Target
Liposome
Related Pathways
Metabolism
Bioactivity
DSPE-PEG (2000) -mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs) . Fluorescently labeled LNPs containing DSPE-PEG (2000) -mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.
Molecular Formula
(C2H4O) nC57H102N3O16PS
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

DSPE-PEG(2000)-Mannose
CAS Number1829524-73-3
PubChem CID177669146
IUPAC Name[(2R)-3-[hydroxy-[2-[2-[2-[[4-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]carbamothioylamino]ethoxy]ethoxycarbonylamino]ethoxy]phosphoryl]oxy-2-octadecanoyloxypropyl] octadecanoate;methane
Molecular FormulaC60H110N3O17PS
Molecular Weight1208.6
Topological Polar Surface Area311
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count18
Rotatable Bond Count55
Heavy Atom Count82
Formal Charge0
Complexity1620
SMILES
C.CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCNC(=O)OCCOCCNC(=S)NC1=CC=C(C=C1)O[C@@H]2[C@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)OC(=O)CCCCCCCCCCCCCCCCC
InChI
InChI=1S/C59H106N3O17PS.CH4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-52(64)74-46-50(77-53(65)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)47-76-80(70,71)75-42-40-61-59(69)73-44-43-72-41-39-60-58(81)62-48-35-37-49(38-36-48)78-57-56(68)55(67)54(66)51(45-63)79-57;/h35-38,50-51,54-57,63,66-68H,3-34,39-47H2,1-2H3,(H,61,69)(H,70,71)(H2,60,62,81);1H4/t50-,51-,54-,55+,56+,57+;/m1./s1
InChIKey
QNVJNURWXNJZFL-AAFOXAMCSA-N
Chemical Structure
2D Structure
2D structure of DSPE-PEG(2000)-Mannose
CAS: 1829524-73-3
CID: 177669146
Formula: C60H110N3O17PS
MW: 1208.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1208.6
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count18
Rotatable Bond Count55
Exact Mass1207.72935722
Monoisotopic Mass1207.72935722
Topological Polar Surface Area311 Ų
Heavy Atom Count82
Formal Charge0
Complexity1620
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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