DSPE-PEG (2000) -Mannose

CAT: 0931-T201883-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T201883-01Size:10 mg
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CAS Number
1829524-73-3
Target
Liposome
Related Pathways
Metabolism
Bioactivity
DSPE-PEG (2000) -mannose, a pegylated and mannosylated derivative of 1,2-DSPE, has been employed in both in vitro and in vivo studies for delivering peptides, oligodeoxynucleotides, and siRNA via liposomes and lipid nanoparticles (LNPs) . Fluorescently labeled LNPs containing DSPE-PEG (2000) -mannose predominantly accumulate in the liver and spleen of mice, significantly more so than in the brain, lungs, heart, kidneys, and pancreas. In immunization studies, liposomes encapsulating Human Papillomavirus type 16 (HPV16) E7 peptides with CpG oligodeoxynucleotides as an adjuvant led to reduced tumor volume and decreased numbers of CD4+ or CD8+ T cells and angiogenesis within tumors in a mouse lung cancer model using TC-1 cells.
Molecular Formula
(C2H4O) nC57H102N3O16PS
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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