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7-acetyl Paclitaxel

CAT: 0931-T201348-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201348-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
92950-39-5
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
7-acetyl Paclitaxel, serving as a microtubule depolymerization inhibitor, can prevent microtubule depolymerization caused by calcium ions at a concentration of 10 μM. Additionally, this compound significantly inhibits the growth of J774.2 macrophages (IC50 = ~60 nM) and elevates levels of nitric oxide (NO) and tumor necrosis factor (TNF) in isolated mouse peritoneal macrophages.
Smiles
O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](OC(C)=O)C[C@]1(OC2)[H])C(=O)[C@H](OC(C)=O)C=4C(C)(C)[C@](O)([C@H]3OC(=O)C5=CC=CC=C5)C[C@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C4C)[H]
Molecular Formula
C49H53NO15
Molecular Weight
895.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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