BRD-K20733377

• Target :

  Bcl-2 Family

• Related Pathways :

  Apoptosis

• Bioactivity :

  BRD-K20733377 is a Bcl-2 inhibitor that exhibits selective cytotoxicity toward senescent cells, specifically inhibiting the activity of etoposide-induced senescent IMR-90 cells with an IC50 of 10.7 ?M. Additionally, BRD-K20733377 reduces the mRNA expression of aging-related genes p16, p21, and KI67 in aged mouse models.

• Smiles :

  O=C(NC1=CC=C(C=C1)S(=O)(=O)NC2=NC=CC=N2)C=3C=CC(=CC3)C=4C=CC=CC4

• Molecular Formula :

  C23H18N4O3S

• Molecular Weight :

  430.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  452350-43-5