CYP3A4-IN-4

CAT: 0931-T201084-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201084-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Cytochromes P450

Related Pathways

Metabolism

Bioactivity

CYP3A4-IN-4 (compound Δ, Λ-3) constitutes a Ru (II) -Ir (III) complex that acts as a photoactive inhibitor of the primary human drug-metabolizing enzyme CYP3A4. This complex features a [Ru (tpy) (Me2bpy) ] photocaging group and exhibits an IC50 of 2.2 μM for the inhibition of microsomal CYP3A4 under irradiation conditions (λirr=530 nm, tirr=15 min) . The phototherapeutic index (PI) of CYP3A4-IN-4 is 5.4.

Smiles

O=C(NC)C1=CC=C(C=C1)NC=2N=CC=3C=C(N(C3N2)CC4=NC=CN=C4N(C)S(=O)(=O)C)C(F)F

Molecular Formula

C80H61Cl3IrN11ORuS2

Molecular Weight

1656.19

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-169217	CYP3A4-IN-4
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CYP3A4-IN-4

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