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EN171

CAT: 0931-T200403-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200403-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2191110-79-7
Target
Estrogen Receptor/ERR, Molecular Glues, Hippo pathway, Others
Related Pathways
Endocrinology/Hormones, PROTAC, Stem Cells, Others
Bioactivity
EN171, a covalent ligand, selectively binds to C38 and C96 on 14-3-3, intensifying 14-3-3's interactions with ERα, YAP, and TAZ. This action impairs both estrogen receptor and Hippo pathway transcriptional activities. Beyond serving as a molecular glue to augment native protein interactions, EN171 also functions as a covalent recruiter for 14-3-3 in heterobifunctional molecules. This facilitates the sequestration of nuclear neo-substrates, such as BRD4 and BLC6, into the cytosol.
Smiles
O=C(C=C)N1CCC2(C1)CN(CC=3C=CC=CC3)CC2
Molecular Formula
C17H22N2O
Molecular Weight
270.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-W1005067-01EN171

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