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SC428

CAT: 0931-T200348-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T200348-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1898232-70-6
Target
Androgen Receptor, Apoptosis
Related Pathways
Apoptosis, Endocrinology/Hormones
Bioactivity
SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.
Smiles
N#CC1=CC=C(C=C1C(F)(F)F)NC(=O)NC=CC=2SC=CC2
Molecular Formula
C15H10F3N3OS
Molecular Weight
337.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 121264601
CAS Number1898232-70-6
PubChem CID121264601
IUPAC Name1-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(E)-2-thiophen-2-ylethenyl]urea
Molecular FormulaC15H10F3N3OS
Molecular Weight337.3
XLogP3.2
Topological Polar Surface Area93.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity500
SMILES
C1=CSC(=C1)/C=C/NC(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F
InChI
InChI=1S/C15H10F3N3OS/c16-15(17,18)13-8-11(4-3-10(13)9-19)21-14(22)20-6-5-12-2-1-7-23-12/h1-8H,(H2,20,21,22)/b6-5+
InChIKey
KACLJUCCGUSGNY-AATRIKPKSA-N
Chemical Structure
2D Structure
2D structure of CID 121264601
CAS: 1898232-70-6
CID: 121264601
Formula: C15H10F3N3OS
MW: 337.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.3
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass337.04966761
Monoisotopic Mass337.04966761
Topological Polar Surface Area93.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity500
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19239018-01SC428

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