HRX-0233

• Target :

  Ras|||MAPK|||Kras

• Related Pathways :

  MAPK

• Bioactivity :

  HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.

• Smiles :

  O=C(C1=CC=C(F)C(NS(=O)(=O)CCC)=C1F)C2=CNC3=NC=C(C=C32)C=4C=NC(=NC4)C5CC5

• Molecular Formula :

  C24H21F2N5O3S

• Molecular Weight :

  497.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2409140-12-9