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Recombinant Human CD80 Protein

CAT: 1510-BRP1155Size: 100 µgDry Ice: NoHazardous: No
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CAT#:1510-BRP1155Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Description
Recombinant human CD80 protein at the C-terminus.
Synonyms
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Source
HEK293 Cells
Applications
SDS-PAGE
Endotoxin
<1.0EU per μg of the protein as determined by the LAL method
Purity
>85% by SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
References & Citations
Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18 (5) : 389-418. Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13 (18 Pt 1) : 5271-9. Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12 (8) : 969-79..
Storage Conditions
Shipat 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.
Formulation
Lyophilized

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