Recombinant human beta-Synuclein protein

Beta-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. beta-synucelin also has a chaperone-like activity. Recently, beta-synuclein has been suggested to inhibit

Beta-synuclein, SNCB beta-Synuclein, B-synuclein, Phosphoneuroprotein 14, PNP14, Synuclein beta

E.coli

Human

Non-Tagged

SDS-PAGE

1 mg/mL (determined by BCA assay)

> 95% by SDS-PAGE

14.2 kDa (134aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

B-Synuclein, Beta-synuclein, SNCB beta-Synuclein, B-synuclein, Beta synuclein, beta synuclein, Phosphoneuroprotein 14, PNP14, Synuclein beta, SNB2001-10 µg, SNB2001-20 µg, SNB2001-50 µg, SNB2001-100 µg, SNB2001-250 µg, SNB2001-500 µg, SNB2001-1 mg, SNB2001-10, SNB2001-20, SNB2001-50, SNB2001-100, SNB2001-250, SNB2001-500, SNB2001-1

Jakes R., et al. (1994) FEBS lett. 345, 27-32.; ; Kim J., et al. (1997) Molecules and Cells. 7, 78-83.; ; Hashimoto M., et al. (2001) Neuron 32, 213-223.;

Ahn KJ, et al. Amino acid sequence motifs and mechanistic features of the membrane translocation of alpha-synuclein. (J Neurochem. 2006) {https://pubmed.ncbi.nlm.nih.gov/16524375/}; ; JY Park, et al. Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinsons disease. (Glia. 2008) {https://pubmed.ncbi.nlm.nih.gov/18449945/}; ; Kim KS, et al. Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. (J Biol Chem. 2010) {https://pubmed.ncbi.nlm.nih.gov/20448034/}; ; Kawakami F, et al. Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β. (FEBS J. 2011) {https://pubmed.ncbi.nlm.nih.gov/21985244/}; ; Konno M, et al. Suppression of dynamin GTPase decreases a-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. (Mol Neurodegener. 2012) {https://pubmed.ncbi.nlm.nih.gov/22892036/}; ; Førland MG, et al. Validation of a new assay for α-synuclein detection in cerebrospinal fluid. (Clin Chem Lab Med. 2017) {https://pubmed.ncbi.nlm.nih.gov/27474841/}; ; Kobayashi J, et al. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. (FASEB J. 2019) {https://pubmed.ncbi.nlm.nih.gov/31211923/}

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl,1mM MgCl2

Neuroscience

NP_001001502.1

Q16143

Human