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Recombinant human Geminin protein

CAT: 0112-GMN0601-020Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0112-GMN0601-020Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Geminin is a 25 kDa protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. In addition, geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions.
Product Name Alternative
GMNN, Geminin, Geminin, DNA replication inhibitor, Gem, Geminin DNA replication inhibitor, OTTHuMP00000039393, RP3 369A17.3.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
27.6 kDa (245aa) confirmed by MALDI-TOF
Additionnal Information
Geminin, GMNN, Geminin, Geminin, DNA replication inhibitor, Gem, Geminin DNA replication inhibitor, OTTHuMP00000039393, RP3 369A17.3., GMN0601-10 µg, GMN0601-20 µg, GMN0601-50 µg, GMN0601-100 µg, GMN0601-250 µg, GMN0601-500 µg, GMN0601-1 mg, GMN0601-10, GMN0601-20, GMN0601-50, GMN0601-100, GMN0601-250, GMN0601-500, GMN0601-1
References & Citations
McGarry TJ. et al (1998) Cell. 93 (6) :1043-53.; ; Pitulescu M. et al (2005) Cell Mol Life Sci. 62 (13) :1425-33.; ; Luo L. et al (2004) Nature. 427 (6976) :749-53;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 20% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_056979.1
Uniprot Accession Number
O75496
Species
Human
AA Sequence
MNPS MKQKQEEIKE NIKNSSVPRR TLKMIQPSAS GSLVGRENEL SAGLSKRKHR NDHLTSTTSS PGVIVPESSE NKNLGGVTQE SFDLMIKENP SSQYWKEVAE KRRKALYEAL KENEKLHKEI EQKDNEIARL KKENKELAEV AEHVQYMAEL IERLNGEPLD NFESLDNQEF DSEEETVEDS LVEDSEIGTC AEGTVSSSTD AKPCI

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