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Human TREM2 antibody

CAT: 0112-ATR0917-050Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0112-ATR0917-050Size:50 µL
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Description
The triggering receptor expressed on myeloid cells-2 (TREM2) is a membrane protein that interacts with the TYROBP protein. The TREM2 and TYROBP proteins form a complex that transmits chemical signals to activate the cell. This complex is involved in the growth and development of several types of immune cells, particularly dendritic cells and activates these cells, triggering an inflammatory response to injury or disease. And the TYROBP-TREM2 complex also activates cells in the skeletal system and in the brain and spinal cord (central nervous system) .
Product Name Alternative
Ttriggering receptor expressed on myeloid cells 2 isoform 1, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on myeloid cells 2a, TREM-2, Trem2a, Trem2b, Trem2c
Host
Mouse
Antigen Species
Human
Reactivity
Human
Immunogen
Recombinant human TREM2 (19-161aa) purified from E. coli
Clonality
Monoclonal
Isotype
IgG3 κ
Clone
2B5
Conjugation
Unconjugated
Applications
ELISA, WB, ICC/IF, FACS
Purification Method
By protein-G affinity chromatography
Concentration
1 mg/mL (determined by BCA assay)
Additionnal Information
TREM2, ATR0917-10 µg, ATR0917-20 µg, ATR0917-50 µg, ATR0917-100 µg, ATR0917-250 µg, ATR0917-500 µg, ATR0917-1 mg, ATR0917-10, ATR0917-20, ATR0917-50, ATR0917-100, ATR0917-250, ATR0917-500, ATR0917-1
References & Citations
N' Diaye EN, et al., (2009) J Cell Biol. 184 (2) :215-23.; ; Piccio L, et al., (2008) Brain. 131 (11) :3081-91.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Applications Notes
The antibody has been tested by ELISA, Western blot, ICC/IF and FACS analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
Scientific Category
Immunology
NCBI Accession Number
NP_061838
Uniprot Accession Number
Q9NZC2
WB Description
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TREM-2 antibody (1:1000) . Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.; ; Lane 1 : 293T cell lysate; ; Lane 2 : TREM2 19-161aa Transfected 293T cell lysate;
FACS Description
Flow cytometry analysis of TREM2 in Hep3B cell line, staining at 2-5ug for 1x10^6cells. The secondary antibody used goat anti-mouse IgG Alexa fluor 488 conjugate.
IF Description
ICC/IF analysis of TREM2 in HepG2 cells. The cell was stained with ATR0917 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .ICC/IF analysis of TREM2 in Raw264.7 cells. The cell was stained with ATR0917 (1:100) . The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue) .{ATR0917-IF2.jpg}

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