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Recombinant human semaphorin-4D protein

CAT: 0112-ATGP4145-010Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP4145-010Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Semaphorin4D, also known as CD100, is a member of the Class 4 family of transmembrane immune and nervous system semaphorins. It is an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. It serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Sema4D, produced by T cells, activated B cells and dendritic cells acts through a low affinity receptor termed CD72 in the immune system. Unligated CD72 inhibits antigen presenting cells that express it, and this inhibition is relieved by Sema4D binding. It is reflected in its ability to inhibit ovarian carcinoma cell survival.Recombinant human semaphorin-4D, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Product Name Alternative
SEMA4D, SEMA-4D, semaphorin-4D isoform 1, semaphorin4D, C9orf164, CD100, coll-4, COLL4, M-sema-G, SEMAJ, previously Sem J, G or C-like 2, A8, BB18, GR3
Expression System
HEK293
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
106.1kDa (952aa)
Additionnal Information
ATGP4145-10 µg, ATGP4145-20 µg, ATGP4145-50 µg, ATGP4145-100 µg, ATGP4145-250 µg, ATGP4145-500 µg, ATGP4145-1 mg, ATGP4145-010, ATGP4145-020, ATGP4145-050, ATGP4145-100, ATGP4145-250, ATGP4145-500, ATGP4145-01M
References & Citations
Kumanogoh, A. and H. Kikutani (2004) Cell. Mol. Life Sci. 61:292-300.; ; Janssen, B.J.C. et al. (2010) Nature 467:1118-1122.; ; Kumanogoh, A. et al. (2005) Int. Immunol. 17:1277-1282.; ; Ishida, I. et al. (2003) Int. Immunol. 15:1027-1034.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology, Adhesion & Movement
NCBI Accession Number
NP_006369
Uniprot Accession Number
Q92854
Species
Human
N Terminal Sequence
Met22

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