Recombinant human CD6 protein

CAT: 0112-ATGP4005-020Size: 20 µgDry Ice: NoHazardous: No
CAT#:0112-ATGP4005-020Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD6, also known as T-cell differentiation antigen CD6, is a member of the group B SRCR (scavenger receptor cysteine-rich) superfamily. CD6 is a cell surface glycoprotein expressed primarily on T cells and It expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. And T-cell differentiation antigen CD6 appears to play a role as both a co-stimulatory molecule in T cell activation and as an adhesion receptor. CD6 binds to CD166 (known as ALCAM), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development.. Certain alleles of this protein may be associated with susceptibility to multiple sclerosis. Recombinant human CD6, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
T-cell differentiation antigen CD6, T12, TP120, CD6, CD_antigen, T-cell differentiation antigen CD6 isform1
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by Absorbance at 280 nm)
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Purity
90% by SDS - PAGE
Bioactivity
Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When cells are added to human CD6 coated plates 10 µg/mL. This effect is more to 50%.
Molecular Weight
68.3kDa (627aa)
Additionnal Information
ATGP4005-10 µg, ATGP4005-50 µg, ATGP4005-100 µg, ATGP4005-200ug, ATGP4005-250 µg, ATGP4005-500 µg, ATGP4005-1 mg, ATGP4005-10 µg, ATGP4005-20 µg, ATGP4005-50 µg, ATGP4005-100 µg, ATGP4005-250 µg, ATGP4005-500 µg, ATGP4005-1 mg, ATGP4005-10, ATGP4005-20, ATGP4005-50, ATGP4005-100, ATGP4005-250, ATGP4005-500, ATGP4005-1
References & Citations
Singer, N.G. et al. (1996) Immunology 88:537-547.; ; Namir J Hassan et al. (2004) Eur J Immunol. 34:930-940.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_006716
Uniprot Accession Number
P30203
Species
Human
N Terminal Sequence
Ala
AA Sequence
HPSPAPP DQLNTSSAES ELWEPGERLP VRLTNGSSSC SGTVEVRLEA SWEPACGALW DSRAAEAVCR ALGCGGAEAA SQLAPPTPEL PPPPAAGNTS VAANATLAGA PALLCSGAEW RLCEVVEHAC RSDGRRARVT CAENRALRLV DGGGACAGRV EMLEHGEWGS VCDDTWDLED AHVVCRQLGC GWAVQALPGL HFTPGRGPIH RDQVNCSGAE AYLWDCPGLP GQHYCGHKED AGAVCSEHQS WRLTGGADRC EGQVEVHFRG VWNTVCDSEW YPSEAKVLCQ SLGCGTAVER PKGLPHSLSG RMYYSCNGEE LTLSNCSWRF NNSNLCSQSL AARVLCSASR SLHNLSTPEV PASVQTVTIE SSVTVKIENK ESRELMLL

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