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Recombinant mouse LRIG1 protein

CAT: 0112-ATGP3937-500Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0112-ATGP3937-500Size:500 µg
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Description
LRIG1, also known as leucine-rich repeats and immunoglobulin-like domains 1 is a pan-negative regulator of the epidermal growth factor receptor (EGFR) signaling pathway. In studies with ErbB family members and Met kinase, LRIG regulates signaling by increasing ubiquitination and lysosomal degradation of the receptors. It functions as a tumor suppressor by controlling cell proliferation through the negative regulation of the EGF family of receptor tyrosine kinases. This protein expression, which is often dysregulated in human cancers, is a prognostic indicator of cancer development and relapse. Recombinant mouse LRIG1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Name Alternative
LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1, D6Bwg0781e, Img
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
84.8kDa (770aa)
Additionnal Information
, ATGP3937-10 µg, ATGP3937-20 µg, ATGP3937-50 µg, ATGP3937-100 µg, ATGP3937-250 µg, ATGP3937-500 µg, ATGP3937-1 mg, ATGP3937-10, ATGP3937-20, ATGP3937-50, ATGP3937-100, ATGP3937-250, ATGP3937-500, ATGP3937-1
References & Citations
JonasNilsson., et al, (2001) Biochem Biophys Res Commun. 284:1155–1161.; ; Gal Gur., et al, (2004) EMBO J. 23:3270–3281.; ; Xi Zhang., et al, (2015) Cell Stress Chaperones. 20:631-641.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_032403
Uniprot Accession Number
P70193
Species
Mouse

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